Today 2C-B is a Schedule I drug, meaning it has no accepted medical use and has a high potential for abuse. While 2C-B is not as popular as other drugs that are typically used at parties and raves, in recent years it has begun appearing more often at nightclubs across the world. The information provided on this website is intended for informational and harm reduction purposes only and does not constitute medical or legal advice. Nor is this information, or any journalistic stories, anecdotes, visual or artistic material intended as a replacement or supplement for medical or legal advice.
Three deaths have been linked to 2C-T-7, one death to 2C-T-21, two deaths to 2C-I-NBOMe, and one death to 2C-E 34–41. It should be noted that there are recent reports of poor clinical outcomes after exposure to unconfirmed 2Cs, including presumed 2C-I-NBOMe (25i). Other published case reports of 2C intoxication are listed in Table 3 41–43. There is little information available about the pharmacology of hallucinogenic 2Cs. It has been shown that 2Cs have an affinity for 5-HT2 and alpha-adrenergic receptors, but these compounds can be either agonists or antagonists, which is dependent on the specific receptor subtype 12–14. It is possible to create new hallucinogenic 2Cs by placing different substituents on the aromatic ring at positions 2, 4, or 5 5, 16.
Reported effects of 2Cs are a combination of hallucinogenic and stimulating effects 20. Patients with 2C intoxication will likely present with either a sympathomimetic syndrome, serotonin toxicity, a hallucinogenic picture, or some combination thereof. Signs and symptoms include hallucinations, euphoria, empathy, nausea, vomiting, agitation, tachycardia, hypertension, respiratory depression, and seizures 1, 2, 6.
It was placed on Schedule One of the Drugs Misuse and Trafficking Act when it first came to notice in 1994, when in a showcase legal battle chemist R. Alexander Shulgin came to Australia to testify on behalf of the defense, to no avail. The onset of a 10-25mg dose (if snorted) will be near instantaneous, with the peak usually occurring around the 2-4 hour mark. The sale of 2C-B is unregulated, and the drug may be tainted with other substances or be a different drug altogether. 2C-B’s chemical name is 4-Bromo-2,5-dimethoxyphenethylamine, and it is synthesized by bromination of 2,5-dimethoxybenzaldehyde.
In higher doses, usually greater than 10 milligrams, the drug has significant hallucinogenic effects. In his book, Shulgin described the intense hallucinations that he and his partner experienced while using 2C-E. Live scenes outside his window suddenly resembled Johannes Vermeer paintings, while an actual painting on his wall appeared to come to life. Tolerance and psychological dependence have been reported in stimulant drugs, such as ecstasy, that act like 2C drugs but little is known about the effects of 2C drugs themselves. Drugs that make you hallucinate can make existing mental health conditions worse. Panic attacks, psychosis, confusion and anxiety are all common risks.
More scientific research needs to be carried out on the long-term effects of 2C-B to determine its potential for causing addiction. Tusi is commonly confused with the 2C family of drugs—psychedelics—because it is a phonetic translation of “2C.” Still, US authorities have pointed to vague international connections.
-B Addiction: Symptoms, Signs & Treatment
If used with 2C-B, Tramadol may lower the seizure threshold, increasing the risk for predisposed individuals. Third Wave’s mission is to nurture the emerging psychedelic ecosystem by providing individuals with research-based education, access to vetted providers, and membership in our global community of psychedelic pioneers. Testing your 2C-B is always good practice even when you trust your supplier. Reagent test kits from Bunk Police can identify hundreds of adulterants and substitutes—offering peace of mind and potentially saving your life. Third Wave’s Ultimate Guide to Sourcing Psychedelic Medicines provides tips and resources to obtain psychedelics in most countries–from trusted sellers. It is illegal in the United States, Canada, the European Union (except the Czech Republic and Portugal), Australia, and more.
Some excited delirium deaths have been thought to be due to ventricular dysythmias and sudden cardiac death related to QT prolongation. However, given the black box warning regarding neuroleptics causing QT prolongation and small risk for ventricular dysrhythmias, if a patient is known to have QT prolongation, neuroleptics may be avoided. Despite this, neuroleptics have a long clinical history of safe use for chemical restraint in undifferentiated agitation and may offer a mechanism by which to regulate dopamine in excited delirium 46, 48–50. Studies by Battaglia and Bieniek et al. showed superior efficacy with a combination of haloperidol and lorazapam as compared to either drug alone for psychotic agitation 49.
What to Expect During a 2C-B Trip
However, the emergence of designer drugs has led to the synthesis of numerous new compounds, each with unique psychoactive profiles 2. Among these, 4-bromo-2,5-dimethoxyphenethylamine, commonly known as 2C/2C-B or colloquially as “pink cocaine,” has gained increasing attention 3,4. Management of acute 2C intoxication consists of focused, symptom-based supportive care.
Recovery Programs
Mixing drugs is always risky but some mixtures are more dangerous than others. 2C-B is a scheduled drug in most jurisdictions.61 The following is a partial list of territories where the substance has been scheduled. Read here to learn more about how long other drugs stay in your system. A liquid version of 2C-I that is applied to the tongue via a pipet has also been reported, though far less common. The Netherlands became the first country in the world to ban 2C-T-2, and classify it as a hard drug, by law.
Yes, the withdrawal symptoms from Tusi can be severe and dangerous, especially since they can be unpredictable and change depending on the exact mixture and ingredients used. The addictive nature of Tusi grows with more frequent use and when it is used along with other drugs or alcohol. It can be difficult to recognize when someone is using Tusi, especially as the signs and symptoms can vary depending on the exact mixture of ingredients.
Therapy can be one of the most effective tools when it comes to treating alcohol and drug abuse, with several types of addiction counseling being particularly useful when treating synthetic drug addiction. The most common type of detox is medically supervised detox, during which the patient is monitored closely and given medications to help with withdrawal management. When someone attempts to stop using Tusi after a period of frequent or long-term use, they are likely to experience uncomfortable withdrawal symptoms. It can be difficult to pinpoint whether someone has an addiction to Tusi, as so many of the signs and symptoms are similar to those with other types of drug use. Still, it is important to know the signs, especially as Tusi grows in popularity.
- While Tusi is not necessarily as addictive as some illicit substances, such as methamphetamines and opioids, it does have the power to result in increased tolerance, physical dependency, and eventually addiction.
- Ketamine therapy is on the rise in light of its powerful results for treatment-resistant depression.
- In this article, we cover 2C-B’s effects, health risks, and the proper response during a potential bad trip or overdose.
- The effects of an oral dose of 2C-B are generally seen one to three hours after intake, and the average duration of effects is between four to eight hours.
- Following the ban, other phenethylamines were sold in place of 2C-B until the Netherlands became the first country in the world to ban 2C-I, 2C-T-2 and 2C-T-7 alongside 2C-B.
Social and Environmental Triggers for Addiction
While hallucinogens are not typically as addictive as other types of drugs, the stimulant aspect of Tusi can make it highly addictive. These withdrawal signs and physical symptoms can range from mild to severe, and may even be life-threatening depending on the composition of the Tusi used. Being able to recognize Tusi addiction in either yourself or a loved one is important and could potentially save a life.
Their services are completely confidential, and their staff is rigorously trained, compassionate, and knowledgeable regarding psychedelics. You can also contact SAMHSA’s National Helpline at (800) 622-HELP (4357). Their confidential helpline is available 24/7 in English and Spanish for individuals and family members experiencing emotional distress or crisis.Additional support resources can be found in the Zendo Project directory. The Zendo Project was founded in partnership with the Multidisciplinary Association for Psychedelic Studies. Horror stories in sensationalist media have portrayed 2C-B as a deadly, threatening drug.5051 And while its toxicity profile has yet to be fully established, such reports are dubious, to say the least. Aside from the fact that aggression and violence are rarely mentioned in users’ reports, 2C-B is difficult to detect in the body.
In March 2025, for instance, Colombian police dismantled a tusi “laboratory” operating out of a private residence, only supplying party-goers in a certain neighborhood of Bogotá. Following the raid, US Attorney General Pam Bondi claimed the club what is the drug 2c was “frequented” by members of the Tren de Aragua and MS-13 gangs. New Johns Hopkins StudyJohns Hopkins University School of Medicines has just published a new study on psychoactive effects of psilocybin. 2C-B feels like a cross between MDMA and LSD but it doesn’t feel like a “candy flip” which is taking LSD and MDMA at the same time. In lower doses, 2C-B is more empathogenic–inducing feelings of connectedness, empathy, and sociability. In higher doses, it tends to be more psychedelic with intense visuals.
Addiction
- In general, Tusi produces effects that are similar to psychedelic drugs like mescaline or LSD with additional stimulant effects.
- Lamotrigine and olanzapine were up-titrated to 50 mg twice a day and 5 mg at night, respectively.
- When experiencing a bad trip or overdose, seek medical attention immediately.
- People may depend on the drug to achieve positive feelings, neglecting aspects of their daily lives to acquire or use it.
- Read our guide on differentiating DMT and near-death experiences to find out.
The hallucinogenic properties of 2C-B are known for producing intense visual and auditory hallucinations, emotional euphoria, and sensory distortions, as well as dissociations similar to ketamine. Additionally, the stimulant properties can cause alertness, increased sociability, and the ability to stay awake longer, like cocaine or MDMA. If one has a preexisting mental health condition or a heart condition, the drug may put these individuals at a higher risk of complications. Psychosis can be triggered in someone with bipolar or schizophrenic disorder. As psychedelics tend to increase one’s heart rate, they also pose a higher risk of complicating preexisting heart conditions. If one is on any medications, such as SSRIs, consult a physician before taking 2C-B.
He also suggested that the drug could be used in conjunction with MDMA to ease the comedown and solidify any revelations brought on by the experience. During the peak, people report enhanced moods and feelings of stimulation, but with less “pushiness” than MDMA. People often describe 2C-B as far more malleable, allowing them to go in and out of baseline consciousness, sometimes abruptly, even during peak effects. Others find themselves dealing with difficult emotions such as anger, grief, and fear. The effects of taking 2C-B with other drugs − including over-the-counter or prescribed medications − can be unpredictable and dangerous. The simplest way to recognize signs of use is through observational study.
